EPC1 Blocking Peptide (Center)

Background:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Other Names:
Enhancer of polycomb homolog 1, EPC1

Target/Specificity:
The synthetic peptide sequence is selected from aa 320-334 of Human EPC1

Gene Name: EPC1 {ECO:0000303|PubMed:10976108, ECO:0000312|HGNC:HGNC:19876}

Gene ID: 80314
Primary Accession: Q9H2F5
Other Accession: Q8C9X6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.