EPC1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7870
Background:
Enhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins. EPC1 interacts with the transcriptional repressor E2F6. In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion. EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor. Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators. The HAT complex may play a role in oncogene/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.
Alternative Name:
Enhancer of polycomb 1, Enhancer of polycomb homolog 1, EPC1, EPC1_HUMAN, Epl 1, Epl1,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: EPC1 polyclonal antibody detects endogenous levels of EPC1 protein.
Immunogen:
Recombinant full length Human EPC1.
MW: ~ 93 kDa
Swis Prot.: Q9H2F5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Enhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins. EPC1 interacts with the transcriptional repressor E2F6. In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion. EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor. Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators. The HAT complex may play a role in oncogene/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.
Alternative Name:
Enhancer of polycomb 1, Enhancer of polycomb homolog 1, EPC1, EPC1_HUMAN, Epl 1, Epl1,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: EPC1 polyclonal antibody detects endogenous levels of EPC1 protein.
Immunogen:
Recombinant full length Human EPC1.
MW: ~ 93 kDa
Swis Prot.: Q9H2F5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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