EphA2 (clone 1B3C7), anti-human
€478.00
In stock
SKU
252652
Protein Family: Enzymes, Protein Kinases, Receptors and Channels
Pathway and Disease: Cancers, Signaling Molecules and Interaction
Description:
EphA2 (EPH receptor A2) is a 976-amino acid protein (~107 kDa) belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers. EphA2 may serves as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.
Alternate Names: Ephrin-A2, EPH-related receptor tyrosine kinase ligand 6, LERK-6, HEK7 ligand, HEK7-L, EPLG6, LERK6, EFNA2
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: O43921
Antigen: Purified recombinant fragment of EphA2 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Signaling Molecules and Interaction
Description:
EphA2 (EPH receptor A2) is a 976-amino acid protein (~107 kDa) belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8, EphA10, EphB1, EphB2, EphB3, EphB4 and EphB6 are Eph family receptors for Ephrin family ligands. In normal cells, EphA2 negatively regulates cell growth and invasiveness. EphA2 is overexpressed by many human cancers, and is often associated with poor prognostic features. The clinical significance of the expression of EphA2 was observed in breast, prostate, colon, skin, cervical, ovarian, and lung cancers. EphA2 may serves as a novel target for bladder cancer, colonic adenocarcinoma and ovarian cancer therapy.
Alternate Names: Ephrin-A2, EPH-related receptor tyrosine kinase ligand 6, LERK-6, HEK7 ligand, HEK7-L, EPLG6, LERK6, EFNA2
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: O43921
Antigen: Purified recombinant fragment of EphA2 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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