EpoR (phospho Tyr426) Polyclonal Antibody

Background:
erythropoietin receptor(EPOR) Homo sapiens This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

Alternative Names:
EPOR, Erythropoietin receptor, EPO-R

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human EpoR (phospho Tyr426)

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 55

GeneID: EPOR

Storage: -20°C/1 year

NOTE: For Research Use Only