ERAF polyclonal, anti-mouse, rat
€388.00
In stock
SKU
BS8238
Background:
α-hemoglobin stabilizing protein (AHSP), also designated erythroid associated factor (ERAF), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of α-hemoglobin during normal erythroid cell development.It specifically protects free α-hemoglobin from precipitation in live cells and in solution. It forms a heterodimer with free α-hemoglobin, but not with β-hemoglobin or hemoglobin A (α2-β-2). AHSP localizes to the cytoplasm and is expressed in the blood and bone marrow. The AHSP protein is downregulated in transmissible spongiform encephalopathies (TSEs). AHSP may regulate pathological states of α-hemoglobin excess such as β-thalassemia,a group of hereditary disorders involving the decreased production of normal adult hemoglobin (HbA) that are characterized by a deficiency in the synthesis of β-globin chains.
Alternative Name:
Alpha-hemoglobin-stabilizing protein, Erythroid differentiation-related factor, Erythroid-associated factor, AHSP, EDRF, ERAF
Application Dilution: WB: 1:500 - 1:2000
Specificity: ERAF polyclonal antibody detects endogenous levels of ERAF protein.
Immunogen:
Recombinant full length Human ERAF.
MW: ~ 12 kDa
Swis Prot.: Q9NZD4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
α-hemoglobin stabilizing protein (AHSP), also designated erythroid associated factor (ERAF), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of α-hemoglobin during normal erythroid cell development.It specifically protects free α-hemoglobin from precipitation in live cells and in solution. It forms a heterodimer with free α-hemoglobin, but not with β-hemoglobin or hemoglobin A (α2-β-2). AHSP localizes to the cytoplasm and is expressed in the blood and bone marrow. The AHSP protein is downregulated in transmissible spongiform encephalopathies (TSEs). AHSP may regulate pathological states of α-hemoglobin excess such as β-thalassemia,a group of hereditary disorders involving the decreased production of normal adult hemoglobin (HbA) that are characterized by a deficiency in the synthesis of β-globin chains.
Alternative Name:
Alpha-hemoglobin-stabilizing protein, Erythroid differentiation-related factor, Erythroid-associated factor, AHSP, EDRF, ERAF
Application Dilution: WB: 1:500 - 1:2000
Specificity: ERAF polyclonal antibody detects endogenous levels of ERAF protein.
Immunogen:
Recombinant full length Human ERAF.
MW: ~ 12 kDa
Swis Prot.: Q9NZD4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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