ERβ polyclonal, anti-human

Background:
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.

Alternative Name:
ESR2, ER-beta, ER BETA, ER-beta, Erb, ESR B, ESR BETA, ESR2, ESR2, ESRB, ESTRB, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, estrogen receptor 2 (ER beta), Estrogen receptor 2, estrogen receptor beta 4, Estrogen receptor beta, NR3A2, Nuclear receptor subfamily 3 group A member 2,

Application Dilution:
WB:1:1,000-1:2,000

Specificity: ERβ polyclonal antibody detects endogenous levels of ERβ protein.

Immunogen:
recombinant protein

MW: 59 kDa

Swiss-Prot: Q92731(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.