ErbB 4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.

Description:
Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4 (ERBB4) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
4ICD antibody, Avian erythroblastic leukemia viral oncogene homolog 4 antibody, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody, E4ICD antibody, EC 2.7.10.1 antibody, ErbB4 antibody, ERBB4 intracellular domain antibody, ERBB4_HUMAN antibody, HER 4 antibody, HER4 antibody, Mer4 antibody, MGC138404 antibody, Oncogene ERBB4 antibody, P180erbB4 antibody, Proto-oncogene-like protein c-ErbB-4 antibody, Receptor protein tyrosine kinase erbB 4 precursor antibody, Receptor tyrosine protein kinase erbB 4 antibody, s80HER4 antibody, Tyrosine kinase type cell surface receptor HER4 antibody, Tyrosine kinase-type cell surface receptor HER4 antibody, v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody, v erb a erythroblastic leukemia viral oncogene homolog 4 antibody, v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian) antibody, V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody, Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody, Verba erythroblastic leukemia viral oncogene homolog 4 antibody, VERBB2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4(35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.