ERCC1 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP14106b
Background:
The product of this gene functions in the nucleotideexcision repair pathway, and is required for the repair of DNAlesions such as those induced by UV light or formed byelectrophilic compounds including cisplatin. The encoded proteinforms a heterodimer with the XPF endonuclease (also known asERCC4), and the heterodimeric endonuclease catalyzes the 5'incision in the process of excising the DNA lesion. Theheterodimeric endonuclease is also involved in recombinational DNArepair and in the repair of inter-strand crosslinks. Mutations inthis gene result in cerebrooculofacioskeletal syndrome, andpolymorphisms that alter expression of this gene may play a role incarcinogenesis. Multiple transcript variants encoding differentisoforms have been found for this gene. The last exon of this geneoverlaps with the CD3e molecule, epsilon associated protein gene onthe opposite strand.
Other Names:
DNA excision repair protein ERCC-1, ERCC1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14106b was selected from the C-term region of ERCC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ERCC1
Gene ID: 2067
Primary Accession: P07992
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The product of this gene functions in the nucleotideexcision repair pathway, and is required for the repair of DNAlesions such as those induced by UV light or formed byelectrophilic compounds including cisplatin. The encoded proteinforms a heterodimer with the XPF endonuclease (also known asERCC4), and the heterodimeric endonuclease catalyzes the 5'incision in the process of excising the DNA lesion. Theheterodimeric endonuclease is also involved in recombinational DNArepair and in the repair of inter-strand crosslinks. Mutations inthis gene result in cerebrooculofacioskeletal syndrome, andpolymorphisms that alter expression of this gene may play a role incarcinogenesis. Multiple transcript variants encoding differentisoforms have been found for this gene. The last exon of this geneoverlaps with the CD3e molecule, epsilon associated protein gene onthe opposite strand.
Other Names:
DNA excision repair protein ERCC-1, ERCC1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14106b was selected from the C-term region of ERCC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ERCC1
Gene ID: 2067
Primary Accession: P07992
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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