ERCC1 antibody (clone 3A7), anti-human
€435.00
In stock
SKU
AC-AT1936a
Catalog Number: AC-AT1936a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT1936a">Request Information
Background:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Other Names:
DNA excision repair protein ERCC-1, ERCC1
Antigen Type:
Recombinant Protein
Gene Name: ERCC1
Gene ID: 2067
NCBI Accession: NP_001159521.1;NP_001974.1;NP_973730.1
Primary Accession: P07992
Other Accession: BC052813
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Other Names:
DNA excision repair protein ERCC-1, ERCC1
Antigen Type:
Recombinant Protein
Gene Name: ERCC1
Gene ID: 2067
NCBI Accession: NP_001159521.1;NP_001974.1;NP_973730.1
Primary Accession: P07992
Other Accession: BC052813
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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