ERCC8 Polyclonal Antibody

Background:
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
ERCC8, CKN1, CSA, UVSS2

Immunogen: A synthetic peptide of human ERCC8 (NP_000073.1).

Swissprot: Q13216
Gene ID: 1161

Calculated MW: 23 kDa/44 kDa
Observed MW: 44 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.