ERF (phospho Thr526) rabbit polyclonal, anti-human, mouse

Backgroud: ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],function:Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation.,PTM:Phosphorylated by multiple kinases including probably ERK2. Phosphorylation regulates the activity of ERF.,sequence caution:The sequence differs from that shown because it seems to be derived from a pre-mRNA.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,tissue specificity:Highest levels in testis, ovary, pancreas, and heart.,

Synonyms: ERF, ETS domain-containing transcription factor ERF, Ets2 repressor factor, PE-2

Gene Name: ERF

Gene ID: 2077

SwissProt ID: P50548

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.