ERG Polyclonal Antibody

Background:
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Stem Cells

Synonyms:
Avian erythroblastosis virus E-26 (v-ets) oncogene related, D030036I24Rik, Erg 3, Erg, ERG/EWS fusion gene, included, ERG/FUS fusion gene, included, ERG/TMPSSR2 fusion gene, included, ERG, ERG1, included, ERG2, included, ets related, ETS-related gene, KCNH2, Oncogene ERG, p55, TMPRSS2/ERG fusion, transcriptional regulator ERG (transforming protein ERG), Transcriptional regulator ERG, Transforming protein ERG, v ets avian erythroblastosis virus E26 oncogene, v ets avian erythroblastosis virus E26 oncogene related, v ets erythroblastosis virus E26 oncogene homolog, v ets erythroblastosis virus E26 oncogene like, v ets erythroblastosis virus E26 oncogene like isoform 2, v-ets erythroblastosis virus E26 oncogene, v-ets erythroblastosis virus E26 oncogene homolog (avian), V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e

Immunogen: Recombinant protein of human ERG

Swissprot: P11308
Gene Accession: BC040168

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18136/sc-354/sc-353/sc-28680