ESR1 polyclonal, anti-human, mouse

Background:
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Synonyms: ER, ESR, ESRA, ESTRR, Era, NR3A1

Cellular Location: Cell membrane Cytoplasm Cytoplasmic side Cytoplasmic side Golgi apparatus Nucleus Peripheral membrane protein Single-pass type I membrane protein

Immunogen:
Recombinant protein of human ESR1

Gene Symbol: ESR1

Gene ID: 2099

Swiss prot: P03372

Calculated MW: 66kDa

Recommended dilution:
WB 1:1000-4000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.