ESRRA polyclonal, anti-human, mouse, rat

Background:
Estrogen related receptor alpha (ERRα) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of α, β and γ). ERRα plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRα has been shown to increase during fasting and cold exposure. ERRα may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRα are unable to maintain their body temperature in the cold. ERRα may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints.

Alternative Name:
ERR-alpha, ESRRA, ERR1, ESRL1, NR3B1, Err 1, ERR a, ERR alpha, ERR-alpha, Err1, ERR1 protein, ERR1, ERRa, ERRalpha, ESRL 1, ESRL1, ESRR A, Esrra, Estrogen receptor like 1, Estrogen receptor related 1, estrogen receptor related receptor alpha, Estrogen receptor-like 1, Estrogen related receptor alpha, Estrogen-related receptor alpha, Estrra, hERR1, NR3B1, Nuclear receptor subfamily 3 group B member 1, Steroid hormone receptor ERR1,

Application Dilution:
WB:1:1,000-1:2,000
FC:1:50-1:100

Specificity: ESRRA polyclonal antibody detects endogenous levels of ESRRA protein.

Immunogen:
recombinant protein

MW: 53 kDa

Swiss-Prot: P11474(Human) O08580(Mouse) Q5QJV7(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.