Estrogen Receptor alpha Polyclonal Antibody

Background:
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction

Synonyms:
ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, ER alpha

Immunogen: Recombinant fusion protein of human Estrogen Receptor alpha (NP_000116.2).

Swissprot: P03372
Gene ID: 2099

Calculated MW: 35 kDa/47 kDa/53 kDa/66 kDa
Observed MW: 75 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:1000-1:4000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.