Estrogen Receptor polyclonal, anti-human

Quantity: 100 µg

Background:
Estrogen receptor alpha (ER-α), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ER-α is encoded by the gene ESR1 (Estrogen Receptor 1). It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.

Description:
Rabbit IgG polyclonal antibody for Estrogen receptor (ESR1) detection. Tested with WB, IHC-P in Human.

Synonyms:
Atherosclerosis, susceptibility to, included antibody, DKFZp686N23123 antibody, ER Alpha antibody, ER antibody, ER Beta antibody, ER-alpha antibody, ER[a] antibody, ER[b] antibody, ERA antibody, ERalpha antibody, Erb antibody, Erb2 antibody, ERbeta antibody, ESR 1 antibody, ESR antibody, ESR BETA antibody, ESR1 antibody, ESR1_HUMAN antibody, ESR2 antibody, ESRA antibody, ESRB antibody, Estr antibody, Estra antibody, Estradiol Receptor alpha antibody, Estradiol Receptor antibody, Estradiol Receptor beta antibody, ESTRB antibody, Estrogen receptor 1 (alpha) antibody, Estrogen receptor 1 antibody, Estrogen receptor 2 (ER beta) antibody, Estrogen Receptor 2 antibody, Estrogen receptor 2 ER beta antibody, Estrogen receptor alpha antibody, Estrogen receptor antibody, Estrogen receptor beta 4 antibody, Estrogen resistance, included antibody, HDL cholesterol, augmented response of, to hormone replacement, included antibody, Myocardial infarction, susceptibility to, included antibody, NR3A 1 antibody, NR3A1 antibody, NR3A2 antibody, Nuclear receptor subfamily 3 group A member 1 antibody, Nuclear receptor subfamily 3 group A member 2 antibody, OTTHUMP00000017718 antibody, OTTHUMP00000017719 antibody, RNESTROR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Estrogen Receptor recombinant protein (Position: F425-V595). Human Estrogen Receptor shares 89% and 88% amino acid (aa) sequences identity with mouse and rat Estrogen Receptor, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.