ETO polyclonal, anti- antibody
€275.00
In stock
SKU
AC-ABV11369-50
Catalog Number: AC-ABV11369-50
Size: 50 µl
Host: Rabbit IgG
Applications: E
Datasheet
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Size: 50 µl
Host: Rabbit IgG
Applications: E
Datasheet
Request Information
Background:
ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t (8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5’-region of AML1 and the 3’-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Other Names:
RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2
Primary Accession: Q06455
Gene Name: RUNX1T1
Gene ID: 862
ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t (8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5’-region of AML1 and the 3’-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Other Names:
RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2
Primary Accession: Q06455
Gene Name: RUNX1T1
Gene ID: 862
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