ETS1 polyclonal, anti-human, mouse

Background:
Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes currently includes Ets-1, Ets-2, Erg-1-3, Elk-1, Elf-1, Elf-5, NERF, PU.1, PEA3, ERM, FEV, ER8l, Fli-1, TEL, Spi-B, ESE-1, ESE-3A, Net, ABT1 and ERF. Members of the Ets gene family exhibit varied patterns of tissue expression, and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. Several of these proteins have been shown to recognize similar motifs in DNA that share a centrally located 5'-GGAA-3' element. Evidence indicates that the DNA binding activity by Ets-1 is regulated at the level of phosphorylation.

Alternative Name:
ETS1, EWSR2, Avian erythroblastosis virus E26 (v ets) oncogene homolog 1, C ets 1 protein, c-ets-1, ETS 1, Ets protein, ETS proto-oncogene 1, transcription factor, ETS1, ETS1 oncogene, ETS1 protein, ETS1, EWSR 2, EWSR2, FLJ10768, Oncogene ETS1, P54, Protein C-ets-1, v ets avian erythroblastosis virus E2 oncogene homolog, v ets avian erythroblastosis virus E2 oncogene homolog 1, v ets avian erythroblastosis virus E26 oncogene homolog 1, v ets erythroblastosis virus E26 oncogene homolog 1, v-ets erythroblastosis virus E26 oncogene homolog 1,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ETS1 polyclonal antibody detects endogenous levels of ETS1 protein.

Immunogen:
Recombinant protein

MW: 50 kDa

Swiss-Prot: P14921(Human) P27577(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.