EWSR1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14576b
Background:
This gene encodes a multifunctional protein that isinvolved in various cellular processes, including gene expression,cell signaling, and RNA processing and transport. The proteinincludes an N-terminal transcriptional activation domain and aC-terminal RNA-binding domain. Chromosomal translocations betweenthis gene and various genes encoding transcription factors resultin the production of chimeric proteins that are involved intumorigenesis. These chimeric proteins usually consist of theN-terminal transcriptional activation domain of this protein fusedto the C-terminal DNA-binding domain of the transcription factorprotein. Mutations in this gene, specifically a t(11;22)(q24;q12)translocation, are known to cause Ewing sarcoma as well asneuroectodermal and various other tumors. Alternative splicing ofthis gene results in multiple transcript variants. Relatedpseudogenes have been identified on chromosomes 1 and 14. [providedby RefSeq].
Other Names:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS
Gene Name: EWSR1
Gene ID: 2130
Primary Accession: Q01844
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a multifunctional protein that isinvolved in various cellular processes, including gene expression,cell signaling, and RNA processing and transport. The proteinincludes an N-terminal transcriptional activation domain and aC-terminal RNA-binding domain. Chromosomal translocations betweenthis gene and various genes encoding transcription factors resultin the production of chimeric proteins that are involved intumorigenesis. These chimeric proteins usually consist of theN-terminal transcriptional activation domain of this protein fusedto the C-terminal DNA-binding domain of the transcription factorprotein. Mutations in this gene, specifically a t(11;22)(q24;q12)translocation, are known to cause Ewing sarcoma as well asneuroectodermal and various other tumors. Alternative splicing ofthis gene results in multiple transcript variants. Relatedpseudogenes have been identified on chromosomes 1 and 14. [providedby RefSeq].
Other Names:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS
Gene Name: EWSR1
Gene ID: 2130
Primary Accession: Q01844
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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