EWSR1 antibody (clone 5C10), anti-human
€435.00
In stock
SKU
AC-AT1961a
Catalog Number: AC-AT1961a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, E
Request Information AC-AT1961a">Request Information
Background:
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Other Names:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS
Antigen Type:
Recombinant Protein
Gene Name: EWSR1
Gene ID: 2130
NCBI Accession: NP_001156757.1;NP_001156758.1;NP_001156759.1;NP_005234.1;NP_053733.2
Primary Accession: Q01844
Other Accession: NM_005243
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Other Names:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWSR1, EWS
Antigen Type:
Recombinant Protein
Gene Name: EWSR1
Gene ID: 2130
NCBI Accession: NP_001156757.1;NP_001156758.1;NP_001156759.1;NP_005234.1;NP_053733.2
Primary Accession: Q01844
Other Accession: NM_005243
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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