EWSR1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5715
Background:
EWS is a nuclear RNA-binding protein. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1 in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various ETS transcription factors, including Fli-1, Erg, ETV1, E1AF and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. Two functional regions have been identified in EWS; an amino-terminal region (domain A), that has little transactivation activity but transforms efficiently when fused to Fli-1, and a distal region (domain B), which shows transactivation activity but transforms less efficiently when fused to Fli-1.
Alternative Name:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWS
Application Dilution: WB: 1:500~1:1000
Specificity: EWSR1 polyclonal antibody detects endogenous levels of EWSR1 protein.
Immunogen:
Synthetic peptide, corresponding to the 465-510 of Human EWSR1.
MW: ~ 68, 90 kDa
Swis Prot.: Q01844
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
EWS is a nuclear RNA-binding protein. As a result of chromosome translocation, the EWS gene is fused to a variety of transcription factors, including ATF-1 in human neoplasias. In the Ewing family of tumors, the N-terminal domain of EWS is fused to the DNA-binding domain of various ETS transcription factors, including Fli-1, Erg, ETV1, E1AF and FEV. The EWS/Fli-1 chimeric protein acts as a more potent transcriptional activator than Fli-1 and can promote cell transformation. Two functional regions have been identified in EWS; an amino-terminal region (domain A), that has little transactivation activity but transforms efficiently when fused to Fli-1, and a distal region (domain B), which shows transactivation activity but transforms less efficiently when fused to Fli-1.
Alternative Name:
RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, EWS
Application Dilution: WB: 1:500~1:1000
Specificity: EWSR1 polyclonal antibody detects endogenous levels of EWSR1 protein.
Immunogen:
Synthetic peptide, corresponding to the 465-510 of Human EWSR1.
MW: ~ 68, 90 kDa
Swis Prot.: Q01844
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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