EWSR1 Polyclonal Antibody

Background:
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Tags and Cell Markers

Synonyms:
bK984G1.4, bK984G1.4 Ewing sarcoma breakpoint region 1 protein, Ewing sarcoma breakpoint region 1, Ewing sarcoma breakpoint region 1 protein, Ewings sarcoma EWS Fli1 type 1 oncogene, EWS, EWS oncogene, EWS RNA binding protein 1, EWS, EWSR 1, Ewsr1, EWSR1 protein, RNA binding protein EWS, RNA-binding protein EWS

Immunogen: Fusion protein of human EWSR1

Swissprot: Q01844
Gene Accession: BC000527

Calculated MW: 68 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.26 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.