EZH2 polyclonal, anti-human
€388.00
In stock
SKU
BS7830
Background:
In Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. PcG proteins work in conjunction with the trithorax-group (trxG), which activate homeobox gene expression during embryonic development. ENX-1, a mammalian homolog of the Drosophila gene enhancer of zeste, is a PcG protein that is ubiquitously expressed during early embryogenesis and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, ENX-1 is restricted to specific sites, including spleen, testis and placenta. The gene encoding human ENX-1 transcribes a 746 amino acid polypeptide which contains a trithorax-like domain and a DNA-binding motif. ENX-1 interacts with the proto-oncogene product Vav and is thought to be involved in the proliferation of normal and malignant hematopoietic cells. By altering the regulation of target genes, ENX-1 may also contribute to certain phenotypes of Down syndrome.
Alternative Name:
Enhancer of zeste 2, Enhancer of zeste homolog 2 (Drosophila), Enhancer of zeste homolog 2, Enhancer of zeste, Drosophila, homolog 2, ENX 1, Enx 1h, ENX-1, ENX1, Enx1h, EZH 2, EZH1, EZH2, EZH2_HUMAN, EZH2b, Histone-lysine N-methyltransferase EZH2, KMT 6, KMT6, KMT6A, Lysine N-methyltransferase 6, MGC9169, WVS, WVS2,
Application Dilution: WB: 1:500 - 1:2000, IP: 1:20 - 1:100
Specificity: EZH2 polyclonal antibody detects endogenous levels of EZH2 protein.
Immunogen:
Recombinant full length Human EZH2.
MW: ~ 85, 100 kDa
Swis Prot.: Q15910
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
In Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci in embryonic development. PcG proteins work in conjunction with the trithorax-group (trxG), which activate homeobox gene expression during embryonic development. ENX-1, a mammalian homolog of the Drosophila gene enhancer of zeste, is a PcG protein that is ubiquitously expressed during early embryogenesis and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, ENX-1 is restricted to specific sites, including spleen, testis and placenta. The gene encoding human ENX-1 transcribes a 746 amino acid polypeptide which contains a trithorax-like domain and a DNA-binding motif. ENX-1 interacts with the proto-oncogene product Vav and is thought to be involved in the proliferation of normal and malignant hematopoietic cells. By altering the regulation of target genes, ENX-1 may also contribute to certain phenotypes of Down syndrome.
Alternative Name:
Enhancer of zeste 2, Enhancer of zeste homolog 2 (Drosophila), Enhancer of zeste homolog 2, Enhancer of zeste, Drosophila, homolog 2, ENX 1, Enx 1h, ENX-1, ENX1, Enx1h, EZH 2, EZH1, EZH2, EZH2_HUMAN, EZH2b, Histone-lysine N-methyltransferase EZH2, KMT 6, KMT6, KMT6A, Lysine N-methyltransferase 6, MGC9169, WVS, WVS2,
Application Dilution: WB: 1:500 - 1:2000, IP: 1:20 - 1:100
Specificity: EZH2 polyclonal antibody detects endogenous levels of EZH2 protein.
Immunogen:
Recombinant full length Human EZH2.
MW: ~ 85, 100 kDa
Swis Prot.: Q15910
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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