EZH2 polyclonal, anti-human, mouse
€484.00
In stock
SKU
254455
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers.
Alternate Names: Enhancer of zeste homolog 2, histone-lysine-N-methylase EZH2, KMT6A, ENX1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: AAH10858
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human EZH2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers.
Alternate Names: Enhancer of zeste homolog 2, histone-lysine-N-methylase EZH2, KMT6A, ENX1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: AAH10858
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human EZH2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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