EZH2 polyclonal (Center), anti-human, mouse
€0.00
In stock
SKU
AC-AP2512c
Catalog Number: AC-AP2512c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2921
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2921
Applications: WB, IHC-P
Datasheet
Request Information
Background:
EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.
Other Names:
Histone-lysine N-methyltransferase EZH2, ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6, EZH2, KMT6
Target/Specificity:
This EZH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from 410-440aa of human EZH2.
Antigen Type: Synthetic Peptide
Gene Name: EZH2 (HGNC:3527)
Gene ID: 2146
Primary Accession: Q15910
NCBI Accession: NP_001190176.1;NP_001190177.1;NP_001190178.1;NP_004447.2;NP_694543.1
Other Accession: Q61188; Q4R381; Q4V863; Q98SM3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.
Other Names:
Histone-lysine N-methyltransferase EZH2, ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6, EZH2, KMT6
Target/Specificity:
This EZH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from 410-440aa of human EZH2.
Antigen Type: Synthetic Peptide
Gene Name: EZH2 (HGNC:3527)
Gene ID: 2146
Primary Accession: Q15910
NCBI Accession: NP_001190176.1;NP_001190177.1;NP_001190178.1;NP_004447.2;NP_694543.1
Other Accession: Q61188; Q4R381; Q4V863; Q98SM3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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