Ezrin monoclonal, anti-human

Description: Anti-Ezrin Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human.

Protein Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis..

Other Names: Ezrin, Cytovillin, Villin-2, p81, EZR, VIL2

Clone Name(s):
Clone: AAAI-5

Subcellular Localization: Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side. Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side)..

Tissue Specificity: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied..

Gene ID: 7430

Immunogen: A synthesized peptide derived from human Ezrin

Calculated MW: 69413

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.