Ezrin (phospho-Y353) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4073
Background:
Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.
Alternative Name:
Cytovillin, Villin-2, Villin2, p81, EZR, VIL2
Application Dilution: WB: 1:500~1:1000
Specificity: p-Ezrin (Y353) polyclonal antibody detects endogenous levels of Ezrin protein only when phosphorylated at Tyr353 .
Immunogen:
Synthetic phosphopeptide derived from human Ezrin around the phosphorylation site of Tyrosine 353.
MW: ~ 69, 81 kDa
Swis Prot.: P15311
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.
Alternative Name:
Cytovillin, Villin-2, Villin2, p81, EZR, VIL2
Application Dilution: WB: 1:500~1:1000
Specificity: p-Ezrin (Y353) polyclonal antibody detects endogenous levels of Ezrin protein only when phosphorylated at Tyr353 .
Immunogen:
Synthetic phosphopeptide derived from human Ezrin around the phosphorylation site of Tyrosine 353.
MW: ~ 69, 81 kDa
Swis Prot.: P15311
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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