F11 antibody (clone 2H8), anti-human
€435.00
In stock
SKU
AC-AT1973a
Catalog Number: AC-AT1973a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E, IP
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E, IP
Request Information AC-AT1973a">Request Information
Background:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Other Names:
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain, F11
Gene Name: F11
Gene ID: 2160
Primary Accession: P03951
Other Accession: NP_000119
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Other Names:
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain, F11
Gene Name: F11
Gene ID: 2160
Primary Accession: P03951
Other Accession: NP_000119
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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