F11 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP11568c
Catalog Number: AC-AP11568c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19294
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19294
Applications: IHC-P, WB
Datasheet
Request Information
Background:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].
Other Names:
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain, F11
Target/Specificity:
This F11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-307 amino acids from the Central region of human F11.
Antigen Region:
281-307
Antigen Type: Synthetic Peptide
Gene Name: F11
Gene ID: 2160
Primary Accession: P03951
NCBI Accession: NP_000119.1
Other Accession: NP_000119.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].
Other Names:
Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain, F11
Target/Specificity:
This F11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-307 amino acids from the Central region of human F11.
Antigen Region:
281-307
Antigen Type: Synthetic Peptide
Gene Name: F11
Gene ID: 2160
Primary Accession: P03951
NCBI Accession: NP_000119.1
Other Accession: NP_000119.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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