F12 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP19282a
Background:
This gene encodes coagulation factor XII which circulatesin blood as a zymogen. This single chain zymogen is converted to atwo-chain serine protease with an heavy chain (alpha-factor XIIa)and a light chain. The heavy chain contains two fibronectin-typedomains, two epidermal growth factor (EGF)-like domains, a kringledomain and a proline-rich domain, whereas the light chain containsonly a catalytic domain. On activation, further cleavages takesplace in the heavy chain, resulting in the production ofbeta-factor XIIa light chain and the alpha-factor XIIa light chainbecomes beta-factor XIIa heavy chain. Prekallikrein is cleaved byfactor XII to form kallikrein, which then cleaves factor XII firstto alpha-factor XIIa and then to beta-factor XIIa. The activefactor XIIa participates in the initiation of blood coagulation,fibrinolysis, and the generation of bradykinin and angiotensin. Itactivates coagulation factors VII and XI. Defects in this gene donot cause any clinical symptoms and the sole effect is thatwhole-blood clotting time is prolonged.
Other Names:
Coagulation factor XII, Hageman factor, HAF, Coagulation factor XIIa heavy chain, Beta-factor XIIa part 1, Beta-factor XIIa part 2, Coagulation factor XIIa light chain, F12
Gene Name: F12
Gene ID: 2161
Primary Accession: P00748
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes coagulation factor XII which circulatesin blood as a zymogen. This single chain zymogen is converted to atwo-chain serine protease with an heavy chain (alpha-factor XIIa)and a light chain. The heavy chain contains two fibronectin-typedomains, two epidermal growth factor (EGF)-like domains, a kringledomain and a proline-rich domain, whereas the light chain containsonly a catalytic domain. On activation, further cleavages takesplace in the heavy chain, resulting in the production ofbeta-factor XIIa light chain and the alpha-factor XIIa light chainbecomes beta-factor XIIa heavy chain. Prekallikrein is cleaved byfactor XII to form kallikrein, which then cleaves factor XII firstto alpha-factor XIIa and then to beta-factor XIIa. The activefactor XIIa participates in the initiation of blood coagulation,fibrinolysis, and the generation of bradykinin and angiotensin. Itactivates coagulation factors VII and XI. Defects in this gene donot cause any clinical symptoms and the sole effect is thatwhole-blood clotting time is prolonged.
Other Names:
Coagulation factor XII, Hageman factor, HAF, Coagulation factor XIIa heavy chain, Beta-factor XIIa part 1, Beta-factor XIIa part 2, Coagulation factor XIIa light chain, F12
Gene Name: F12
Gene ID: 2161
Primary Accession: P00748
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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