F12 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS6601
Background:
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).
Alternative Name:
Factor XII, Beta factor XIIa part 1, Beta factor XIIa part 2, Coagulation factor XII, Coagulation factor XIIa heavy chain, Coagulation factor XIIa light chain, F12, F12 deficiency, FA12, Factor XII, Factor XII deficiency, HAE3, HAEX, HAF, HAF deficiency, Hageman factor,
Application Dilution: WB: 1:500 - 1:2000
Specificity: F12 polyclonal antibody detects endogenous levels of F12 protein.
Immunogen:
Recombinant full length Human F12.
MW: ~ 68 kDa
Swis Prot.: P00748
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).
Alternative Name:
Factor XII, Beta factor XIIa part 1, Beta factor XIIa part 2, Coagulation factor XII, Coagulation factor XIIa heavy chain, Coagulation factor XIIa light chain, F12, F12 deficiency, FA12, Factor XII, Factor XII deficiency, HAE3, HAEX, HAF, HAF deficiency, Hageman factor,
Application Dilution: WB: 1:500 - 1:2000
Specificity: F12 polyclonal antibody detects endogenous levels of F12 protein.
Immunogen:
Recombinant full length Human F12.
MW: ~ 68 kDa
Swis Prot.: P00748
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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