F2 Polyclonal Antibody

Background:
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology, Cardiovascular, Signal Transduction

Synonyms:
F2, PT, RPRGL2, THPH1

Immunogen: Recombinant fusion protein of human F2 (NP_000497.1).

Swissprot: P00734
Gene ID: 2147

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IF 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.