F3 Polyclonal Antibody

Background:
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

Research Area: Cancer, Cardiovascular

Synonyms:
CD142, CD142 antigen, Coagulation factor III (thromboplastin tissue factor), Coagulation factor III, F3, FLJ17960, TF, TF, TFA, Thromboplastin, Tissue factor

Immunogen: Synthetic peptide of human F3

Swissprot: P13726
Gene Accession: NP001984

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.3 mg/mL
Dilution: IHC 1:40-1:250, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.