F8 antibody (clone 100000000), anti-human
€435.00
In stock
SKU
AC-AT1980a
Catalog Number: AC-AT1980a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: E
Request Information AC-AT1980a">Request Information
Background:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Other Names:
Coagulation factor VIII, Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain, F8, F8C
Antigen Type:
Recombinant Protein
Gene Name: F8
Gene ID: 2157
NCBI Accession: NP_000123.1;NP_063916.1
Primary Accession: P00451
Other Accession: NM_000132
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Other Names:
Coagulation factor VIII, Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain, F8, F8C
Antigen Type:
Recombinant Protein
Gene Name: F8
Gene ID: 2157
NCBI Accession: NP_000123.1;NP_063916.1
Primary Accession: P00451
Other Accession: NM_000132
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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