Factor B (clone KT21), anti-human
€395.00
In stock
SKU
250119
Protein Family: Enzymes
Pathway and Disease: Immune System
Description:
The complement factor B is part of the alternate pathway of the complement system. Factor B is cleaved by factor D into two fragments, Ba and Bb, the latter being a serine protease that binds to complement component 3b (C3b) to generate the C3 or C5 convertase. Factor B is involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Among the 15 variants of factor B gene, the variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD). This antibody recognizes human complement factor B in indirect and sandwich ELISA.
Alternate Names: Complement factor B, C3/C5 convertase, Properdin factor B, Glycine-rich beta glycoprotein, GBG, PBF2, Ba fragment, Bb fragment, CFB, BF, BFD
Application Notes: E: 5 mg/ml
Accession No.: P00751, NP_001701
Antigen: Purified human complement factor B protein
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Immune System
Description:
The complement factor B is part of the alternate pathway of the complement system. Factor B is cleaved by factor D into two fragments, Ba and Bb, the latter being a serine protease that binds to complement component 3b (C3b) to generate the C3 or C5 convertase. Factor B is involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Among the 15 variants of factor B gene, the variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD). This antibody recognizes human complement factor B in indirect and sandwich ELISA.
Alternate Names: Complement factor B, C3/C5 convertase, Properdin factor B, Glycine-rich beta glycoprotein, GBG, PBF2, Ba fragment, Bb fragment, CFB, BF, BFD
Application Notes: E: 5 mg/ml
Accession No.: P00751, NP_001701
Antigen: Purified human complement factor B protein
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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