Factor XIIIa Polyclonal Antibody

Background:
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Research Area: Cancer, Cardiovascular, Tags and Cell Markers

Synonyms:
bA525O21.1 (coagulation factor XIII, A1 polypeptide), Coagulation factor XIII A chain, Coagulation factor XIII A1 polypeptide, Coagulation factor XIII A1 subunit, Coagulation factor XIII, A polypeptide, Coagulation factor XIIIa, F13A, F13A, F13a1, Factor XIIIA, Fibrin stabilizing factor, A subunit, Fibrinoligase, FSF, A subunit, Protein glutamine gamma glutamyltransferase A chain, Protein-glutamine gamma-glutamyltransferase A chain, TGase, Transglutaminase A chain, Transglutaminase, plasma, Transglutaminase. plasma

Immunogen: Synthetic peptide of human F13A1

Swissprot: P00488
Gene Accession: NP_000120

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.1 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18013/sc-292288