FADD Antibody(Center) Blocking peptide
€363.00
In stock
SKU
AC-BP19607c
Background:
The protein encoded by this gene is an adaptor moleculethat interacts with various cell surface receptors and mediatescell apoptotic signals. Through its C-terminal death domain, thisprotein can be recruited by TNFRSF6/Fas-receptor, tumor necrosisfactor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus itparticipates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks theN-terminal effector domain of this protein, which allows it torecruit caspase-8, and thereby activate the cysteine proteasecascade. Knockout studies in mice also suggest the importance ofthis protein in early T cell development.
Other Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Gene Name: FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}
Gene ID: 8772
Primary Accession: Q13158
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is an adaptor moleculethat interacts with various cell surface receptors and mediatescell apoptotic signals. Through its C-terminal death domain, thisprotein can be recruited by TNFRSF6/Fas-receptor, tumor necrosisfactor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus itparticipates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks theN-terminal effector domain of this protein, which allows it torecruit caspase-8, and thereby activate the cysteine proteasecascade. Knockout studies in mice also suggest the importance ofthis protein in early T cell development.
Other Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Gene Name: FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}
Gene ID: 8772
Primary Accession: Q13158
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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