FADD antibody (clone 3A12), anti-human
€435.00
In stock
SKU
AC-AT1988a
Catalog Number: AC-AT1988a
Size: 100 µg
Isotype: mouse IgG1 lambda
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 lambda
Applications: WB, E
Request Information AC-AT1988a">Request Information
Background:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Other Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Antigen Type:
Recombinant Protein
Gene Name: FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}
Gene ID: 8772
NCBI Accession: NP_003815.1
Primary Accession: Q13158
Other Accession: BC000334
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Other Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Antigen Type:
Recombinant Protein
Gene Name: FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}
Gene ID: 8772
NCBI Accession: NP_003815.1
Primary Accession: Q13158
Other Accession: BC000334
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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