FADD (clone 5E8-A7), anti-human

Background:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals.Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor,tumor necrosis factor receptor,TNFRSF25,and TNFSF10/TRAIL-receptor,and thus it participates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein,which allows it to recruit caspase-8,and thereby activate the cysteine protease cascade.Knockout studies in mice also suggest the importance of this protein in early T cell development.[provided by RefSeq,Jul 2008]

Synonyms: FADD

Cellular Location: Cytosol Nucleus Plasma Membrane

Immunogen:
Recombinant human FADD protein.

Gene Symbol: FADD

Gene ID: 8772

Swiss prot: Q13158

Calculated MW: 28kDa

Recommended dilution:
WB 1:500

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.