FADD Polyclonal Antibody

Background:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Research Area: Cancer, Cell Biology

Synonyms:
FADD, FADD protein, FADD, Fas (TNFRSF6) associated via death domain, Fas associated via death domain, Fas associating death domain containing protein, Fas associating protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, FAS-associated death domain protein, FAS-associating death domain-containing protein, GIG 3, GIG3, Growth inhibiting gene 3 protein, Growth-inhibiting gene 3 protein, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity, MGC8528, MORT 1, MORT1, Protein FADD

Immunogen: Recombinant protein of human FADD

Swissprot: Q13158
Gene Accession: BC000334

Calculated MW: 23 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6035/sc-5559