Aurora Kinase A monoclonal, anti-human
€470.00
In stock
SKU
AC-AP52717
Catalog Number: AC-AP55069
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Other Names:
AIK;ARK-1;ARK1;AURA;AURKA;Aurora 2;Aurora A;Aurora Family Kinase 1;aurora kinase A;Aurora Related Kinase 1;Aurora-related kinase 1;Aurora/IPL1 Like Kinase; Aurora/IPL1 Related Kinase 1;Aurora/IPL1-related kinase 1;AURORA2;AYK1;BRAK;Breast Tumor Amplified Kinase;Breast tumor-amplified kinase;BTAK;hARK1;IAK ;IPL1 Aurora Related Kinase 1;IPL1 Related Kinase;MGC34538;OTTHUMP00000031340;OTTHUMP00000031341;OTTHUMP00000031342;OTTHUMP00000031343;OTTHUMP00000031344; OTTHUMP00000031345;OTTHUMP00000166071;OTTHUMP00000166072;PPP1R47;Protein phosphatase 1, regulatory subunit 47;Serine/threonine kinase 15;Serine/threonine kinase 6;Serine/threonine kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A;STK15;STK6; STK6_HUMAN;STK7.
Antigen Type: Recombinant Protein
Antigen Type: AURKA (HGNC:11393)
Gene ID: 6790
Primary Accession: O14965
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Other Names:
AIK;ARK-1;ARK1;AURA;AURKA;Aurora 2;Aurora A;Aurora Family Kinase 1;aurora kinase A;Aurora Related Kinase 1;Aurora-related kinase 1;Aurora/IPL1 Like Kinase; Aurora/IPL1 Related Kinase 1;Aurora/IPL1-related kinase 1;AURORA2;AYK1;BRAK;Breast Tumor Amplified Kinase;Breast tumor-amplified kinase;BTAK;hARK1;IAK ;IPL1 Aurora Related Kinase 1;IPL1 Related Kinase;MGC34538;OTTHUMP00000031340;OTTHUMP00000031341;OTTHUMP00000031342;OTTHUMP00000031343;OTTHUMP00000031344; OTTHUMP00000031345;OTTHUMP00000166071;OTTHUMP00000166072;PPP1R47;Protein phosphatase 1, regulatory subunit 47;Serine/threonine kinase 15;Serine/threonine kinase 6;Serine/threonine kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A;STK15;STK6; STK6_HUMAN;STK7.
Antigen Type: Recombinant Protein
Antigen Type: AURKA (HGNC:11393)
Gene ID: 6790
Primary Accession: O14965
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