FAK (clone 3D8-H11-E12), anti-human

Background:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

Synonyms: FADK, FAK, FAK1, FRNK, p125FAK, pp125FAK, PPP1R71

Cellular Location: Cell junction Cell membrane Cytoplasm Cytoplasmic side Nucleus Peripheral membrane protein cell cortex centrosome cytoskeleton focal adhesion microtubule organizing center

Immunogen:
Purified recombinant human FAK protein fragments expressed in E.coli.

Gene Symbol: FAK

Gene ID: 5747

Swiss prot: Q05397

Calculated MW: 125kDa

Recommended dilution:
WB 1:1000, ICC 1:200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.