FAK Polyclonal Antibody

Background:
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cardiovascular, Signal Transduction

Synonyms:
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, PTK2

Immunogen: A synthetic peptide of human FAK (NP_722560.1).

Swissprot: Q05397
Gene ID: 5747

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.