FANCD2 polyclonal, anti-human
€388.00
In stock
SKU
BS6604
Background:
Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451-amino acid nuclear protein that exists as 2 protein isoforms.
Alternative Name:
Fanconi anemia group D2 protein, FACD2, FANCD2, FACD
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: FANCD2 polyclonal antibody detects endogenous levels of FANCD2 protein.
Immunogen:
Recombinant full length Human FANCD2.
MW: ~ 166 kDa
Swis Prot.: Q9BXW9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451-amino acid nuclear protein that exists as 2 protein isoforms.
Alternative Name:
Fanconi anemia group D2 protein, FACD2, FANCD2, FACD
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:100
Specificity: FANCD2 polyclonal antibody detects endogenous levels of FANCD2 protein.
Immunogen:
Recombinant full length Human FANCD2.
MW: ~ 166 kDa
Swis Prot.: Q9BXW9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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