FANCD2 polyclonal (Center), anti-human
€235.00
In stock
SKU
AC-AP21536c-ev
Catalog Number: AC-AP21536c-ev
Size: 80 µl
Isotype: Rabbit IgG
Clone Name: RB49367
Applications: WB
Datasheet
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Size: 80 µl
Isotype: Rabbit IgG
Clone Name: RB49367
Applications: WB
Datasheet
Request Information
Background:
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Other Names:
Fanconi anemia group D2 protein, Protein FACD2, FANCD2, FACD
Target/Specificity:
This FANCD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 893-927 amino acids from the Central region of human FANCD2.
Gene Name: FANCD2
Gene ID: 2177
Primary Accession: Q9BXW9
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Other Names:
Fanconi anemia group D2 protein, Protein FACD2, FANCD2, FACD
Target/Specificity:
This FANCD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 893-927 amino acids from the Central region of human FANCD2.
Gene Name: FANCD2
Gene ID: 2177
Primary Accession: Q9BXW9
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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