FANCL Peptide
€100.00
In stock
SKU
350524
Protein Family: Enzymes, Ubiquitins
Pathway and Disease: Cancers, Folding, Sorting and Degradation, Replication and Repair
Alternate Names: E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; FANCL; PHF9
Accession No.: Q9NW38, NP_060532
Description:
Fanconi anemia group L protein (FANCL) is an ubiquitin ligase that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. FANCL is required for proper primordial germ cell proliferation in the embryonic stage. Defects in FANCA are the cause of Fanconi anemia, a syndrome characterized by pancytopenia, congenital malformations and predisposition to cancers caused by a hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 2031.2 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200162 is selected from a sequence within the N-term region of human FANCL. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C85H135N27O29S1
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
Pathway and Disease: Cancers, Folding, Sorting and Degradation, Replication and Repair
Alternate Names: E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; FANCL; PHF9
Accession No.: Q9NW38, NP_060532
Description:
Fanconi anemia group L protein (FANCL) is an ubiquitin ligase that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. FANCL is required for proper primordial germ cell proliferation in the embryonic stage. Defects in FANCA are the cause of Fanconi anemia, a syndrome characterized by pancytopenia, congenital malformations and predisposition to cancers caused by a hypersensitivity to DNA-damaging agents, chromosomal instability and defective DNA repair.
Format:
Each vial contains 0.1 mg of lyophilized peptide. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
MW: 2031.2 g/mol
Sequence:
The synthetic peptide used to raise the antibody Cat. No. 200162 is selected from a sequence within the N-term region of human FANCL. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
Composition:
C85H135N27O29S1
Purity:
> 80% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
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