FAS Antibody (Center Y232) Blocking peptide
€363.00
In stock
SKU
AC-BP12628c
Background:
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor contains a death domain. Ithas been shown to play a central role in the physiologicalregulation of programmed cell death, and has been implicated in thepathogenesis of various malignancies and diseases of the immunesystem. The interaction of this receptor with its ligand allows theformation of a death-inducing signaling complex that includesFas-associated death domain protein (FADD), caspase 8, and caspase10. The autoproteolytic processing of the caspases in the complextriggers a downstream caspase cascade, and leads to apoptosis. Thisreceptor has been also shown to activate NF-kappaB, MAPK3/ERK1, andMAPK8/JNK, and is found to be involved in transducing theproliferating signals in normal diploid fibroblast and T cells. Atleast eight alternatively spliced transcript variants have beendescribed, some of which are candidates for nonsense-mediated decay(NMD). The isoforms lacking the transmembrane domain may negativelyregulate the apoptosis mediated by the full length isoform.
Other Names:
Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, TNFRSF6
Gene Name: FAS
Gene ID: 355
Primary Accession: P25445
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor contains a death domain. Ithas been shown to play a central role in the physiologicalregulation of programmed cell death, and has been implicated in thepathogenesis of various malignancies and diseases of the immunesystem. The interaction of this receptor with its ligand allows theformation of a death-inducing signaling complex that includesFas-associated death domain protein (FADD), caspase 8, and caspase10. The autoproteolytic processing of the caspases in the complextriggers a downstream caspase cascade, and leads to apoptosis. Thisreceptor has been also shown to activate NF-kappaB, MAPK3/ERK1, andMAPK8/JNK, and is found to be involved in transducing theproliferating signals in normal diploid fibroblast and T cells. Atleast eight alternatively spliced transcript variants have beendescribed, some of which are candidates for nonsense-mediated decay(NMD). The isoforms lacking the transmembrane domain may negativelyregulate the apoptosis mediated by the full length isoform.
Other Names:
Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, TNFRSF6
Gene Name: FAS
Gene ID: 355
Primary Accession: P25445
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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