FAS Polyclonal Antibody

Background:
Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells,or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.

Research Area: Cancer, Cell Biology, Immunology

Synonyms:
ALPS 1A, ALPS1A, APO 1, Apo 1 antigen, APO 1 cell surface antigen, Apo-1 antigen, APO1, Apo1 antigen, APO1 cell surface antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, APT 1, APT1, CD 95, CD 95 antigen, CD95, CD95 antigen, Delta Fas, Delta Fas/APO 1/CD95, Delta Fas/APO1/CD95, Fas (TNF receptor superfamily, member 6), FAS 1, FAS 827dupA, Fas AMA, Fas, FAS Antigen, Fas cell surface death receptor, FAS1, FASLG receptor, FASTM, sFAS, Surface antigen APO1, TNF receptor superfamily, member 6, TNFRSF 6, TNFRSF6, TNR6, Tumor necrosis factor receptor superfamily member 6

Immunogen: Recombinant human Tumor necrosis factor receptor superfamily member 6 protein

Swissprot: P25445
Gene Accession: BC012479

Calculated MW: 37 kDa
Observed MW: 45 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 2 mg/mL
Dilution: WB 1:500-1:1000, IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7886,sc-715,sc-714

Citation(s):
https://www.mdpi.com/1422-0067/20/3/757
https://pubmed.ncbi.nlm.nih.gov/31472955/
https://pubmed.ncbi.nlm.nih.gov/32485087/