FBXL18 polyclonal, anti-human, mouse
€428.00
In stock
SKU
BS9962M
Background:
FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination.
Alternative Name:
F-box/LRR-repeat protein 18, F-box and leucine-rich repeat protein 18, FBXL18, FBL18
Application Dilution: WB: 1:500, IHC: 1:50-1:200, FC: 1:50-1:100
Specificity: This antibody detects endogenous levels of FBXL18 and does not cross-react with related proteins.
Immunogen:
Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.
MW: ~ 40, 88 kDa
Swis Prot.: Q96ME1
Purification & Purity:
Protein A affinity purified.
Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination.
Alternative Name:
F-box/LRR-repeat protein 18, F-box and leucine-rich repeat protein 18, FBXL18, FBL18
Application Dilution: WB: 1:500, IHC: 1:50-1:200, FC: 1:50-1:100
Specificity: This antibody detects endogenous levels of FBXL18 and does not cross-react with related proteins.
Immunogen:
Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.
MW: ~ 40, 88 kDa
Swis Prot.: Q96ME1
Purification & Purity:
Protein A affinity purified.
Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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