FBXL18 polyclonal, anti-human, mouse, rat

Background:
FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.

Alternative Name:
FBXL18, FBL18, F box and leucine rich repeat protein 18, F box/LRR repeat protein 18, FBL18, FBXL 18, FLJ10776, FLJ11467, FLJ26934, FLJ38075, FLJ41541,

Application Dilution:
WB:1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: FBXL18 polyclonal antibody detects endogenous levels of FBXL18 protein.

Immunogen:
Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.

MW: 88/40 kDa

Swiss-Prot: Q96ME1(Human)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.